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Advanced analysis for structural steel building design
CHEN Wai Fah
《结构与土木工程前沿(英文)》 2008年 第2卷 第3期 页码 189-196 doi: 10.1007/s11709-008-0024-8
关键词: building Specifications comprehensive introduction structural resistance traditional
杜斌,向天宇,赵人达
《中国工程科学》 2010年 第12卷 第3期 页码 108-112
为了对既有结构的可靠性进行正确评估,必须考虑时间变化的影响,对目前可靠度分析中采用的只考虑荷载随时间变化的半随机过程模型进行改进。基于结构抗力和作用效应相互独立的基本假设,充分依据作用效应和抗力的时变特性,考虑结构抗力为独立增量过程,并计算了抗力的自相关系数,得到了计算结构失效概率的近似算法,建立了结构时变可靠度计算的全随机过程模型。通过实例验证,该方法简单易行,便于工程应用,为基于时变可靠度理论的既有结构评估和寿命预测提供理论依据。
Prevalence of antifolate drug resistance markers in in China
《医学前沿(英文)》 2022年 第16卷 第1期 页码 83-92 doi: 10.1007/s11684-021-0894-x
关键词: drug resistance antifolates molecular markers Plasmodium vivax China
Metagenomic analysis on resistance genes in water and microplastics from a mariculture system
《环境科学与工程前沿(英文)》 2022年 第16卷 第1期 页码 4-4 doi: 10.1007/s11783-021-1438-y
Microplastics existing widely in different matrices have been regarded as a reservoir for emerging contaminants. Mariculture systems have been observed to host microplastics and antibiotic resistance genes (ARGs). However, more information on proliferation of ARGs and metal resistance genes (MRGs) in mariculture system at the presence of microplastics is needed.
关键词: Antibiotic resistance genes Metal resistance genes Metagenomic analysis Microplastics Mariculture
Approximation of structural damping and input excitation force
Mohammad SALAVATI
《结构与土木工程前沿(英文)》 2017年 第11卷 第2期 页码 244-254 doi: 10.1007/s11709-016-0371-9
关键词: structural modal parameters damping identification method input excitation force identification Inverse problem
Taking advantage of drug resistance, a new approach in the war on cancer
null
《医学前沿(英文)》 2018年 第12卷 第4期 页码 490-495 doi: 10.1007/s11684-018-0647-7
Identification of the driver mutations in cancer has resulted in the development of a new category of molecularly targeted anti-cancer drugs. However, as was the case with conventional chemotherapies, the effectiveness of these drugs is limited by the emergence of drug-resistant variants. While most cancer therapies are given in combinations that are designed to avoid drug resistance, we discuss here therapeutic approaches that take advantage of the changes in cancer cells that arise upon development of drug resistance. This approach is based on notion that drug resistance comes at a fitness cost to the cancer cell that can be exploited for therapeutic benefit. We discuss the development of sequential drug therapies in which the first therapy is not given with curative intent, but to induce a major new sensitivity that can be targeted with a second drug that selectively targets the acquired vulnerability. This concept of collateral sensitivity has hitherto not been used on a large scale in the clinic and holds great promise for future cancer therapy.
关键词: cancer drug resistance genetic screens senescence targeted therapy
Targeting apoptosis to manage acquired resistance to third generation EGFR inhibitors
《医学前沿(英文)》 2022年 第16卷 第5期 页码 701-713 doi: 10.1007/s11684-022-0951-0
关键词: acquired resistance EGFR inhibitor apoptosis lung cancer
Effects of green roof damping and configuration on structural seismic response
《结构与土木工程前沿(英文)》 页码 1133-1144 doi: 10.1007/s11709-023-0959-9
关键词: green infrastructure green roof structural resilience seismic design
Xinqun ZHU, Hong HAO
《结构与土木工程前沿(英文)》 2012年 第6卷 第3期 页码 321-333 doi: 10.1007/s11709-012-0161-y
关键词: integrated structural health monitoring operational conditions vibration and guided wave
Transmission of antibiotic resistance genes in agroecosystems: an overview
Jizheng HE, Zhenzhen YAN, Qinglin CHEN
《农业科学与工程前沿(英文)》 2020年 第7卷 第3期 页码 329-332 doi: 10.15302/J-FASE-2020333
The use of antibiotics in human medicine and animal husbandry has resulted in the continuous release of antibiotics into the environment, which imposes high selection pressure on bacteria to develop antibiotic resistance. The spread and aggregation of antibiotic resistance genes (ARGs) in multidrug-resistant pathogens is one of the most intractable clinical challenges. Numerous studies have been conducted to profile the patterns of ARGs in agricultural ecosystems, as this is closely related to human health and wellbeing. This paper provides an overview of the transmission of ARGs in agricultural ecosystems resulting from the application of animal manures and other organic amendments. The future need to control and mitigate the spread of antibiotic resistance in agricultural ecosystems is also discussed, particularly from a holistic perspective, and requires multiple sector efforts to translate fundamental knowledge into effective strategies.
关键词: agroecosystem antibiotic resistance public health soil-plant system
《环境科学与工程前沿(英文)》 2021年 第15卷 第5期 doi: 10.1007/s11783-020-1342-x
• SMX addition had negative effect on acetoclastic methanogens in mesophilic AD.
关键词: Pig manure Antibiotics Anaerobic digestion Resistance genes Microbial community
Digital image correlation-based structural state detection through deep learning
《结构与土木工程前沿(英文)》 2022年 第16卷 第1期 页码 45-56 doi: 10.1007/s11709-021-0777-x
关键词: structural state detection deep learning digital image correlation vibration signal steel frame
Menglu Zhang, Sheng Chen, Xin Yu, Peter Vikesland, Amy Pruden
《环境科学与工程前沿(英文)》 2019年 第13卷 第3期 doi: 10.1007/s11783-019-1124-5
Extracellular DNA structure damaged by chlorination was characterized. Integrity of extracellular ARG genetic information after chlorination was determined. Typical chlorine doses will likely effectively diminish extracellular DNA and ARGs. Plasmid DNA/ARGs were less readily broken down than genomic DNA. The Bioanalyzer methodology effectively documented damage incurred to DNA.
关键词: Antibiotic resistance Antibiotic resistance genes (ARGs) Extracellular DNA/ARGs Chlorination
Ali KARIMPOUR, Salam RAHMATALLA
《结构与土木工程前沿(英文)》 2020年 第14卷 第6期 页码 1331-1348 doi: 10.1007/s11709-020-0686-4
关键词: structural model validation eigenvalue problem response surface inverse problems
Insulin resistance and the metabolism of branched-chain amino acids
null
《医学前沿(英文)》 2013年 第7卷 第1期 页码 53-59 doi: 10.1007/s11684-013-0255-5
Insulin resistance (IR) is a key pathological feature of metabolic syndrome and subsequently causes serious health problems with an increased risk of several common metabolic disorders. IR related metabolic disturbance is not restricted to carbohydrates but impacts global metabolic network. Branched-chain amino acids (BCAAs), namely valine, leucine and isoleucine, are among the nine essential amino acids, accounting for 35% of the essential amino acids in muscle proteins and 40% of the preformed amino acids required by mammals. The BCAAs are particularly responsive to the inhibitory insulin action on amino acid release by skeletal muscle and their metabolism is profoundly altered in insulin resistant conditions and/or insulin deficiency. Although increased circulating BCAA concentration in insulin resistant conditions has been noted for many years and BCAAs have been reported to be involved in the regulation of glucose homeostasis and body weight, it is only recently that BCAAs are found to be closely associated with IR. This review will focus on the recent findings on BCAAs from both epidemic and mechanistic studies.
关键词: branched-chain amino acids leucine isoleucine valine insulin resistance
标题 作者 时间 类型 操作
Development of an integrated structural health monitoring system for bridge structures in operational
Xinqun ZHU, Hong HAO
期刊论文
Transmission of antibiotic resistance genes in agroecosystems: an overview
Jizheng HE, Zhenzhen YAN, Qinglin CHEN
期刊论文
swine manure with sulfamethoxazole and norfloxacin: Dynamics of microbial communities and evolution of resistance
期刊论文
Degradation of extracellular genomic, plasmid DNA and specific antibiotic resistance genes by chlorination
Menglu Zhang, Sheng Chen, Xin Yu, Peter Vikesland, Amy Pruden
期刊论文
Identification of structural parameters and boundary conditions using a minimum number of measurement
Ali KARIMPOUR, Salam RAHMATALLA
期刊论文